The Brennan-Krohn Laboratory

Antibiotic resistance in gram-negative pathogens, including Enterobacterales (E. coli, Klebsiella, Enterobacter, etc.) and "non-fermenting" organisms (Pseudomonas aeruginosa, Acinetobacter baumanni, Burkholderia cepacia complex, Stenotrophomonas maltophilia, etc.) is complex, multifactorial, and constantly changing. New antibiotic development is unable to keep pace with the emergence and evolution of resistance. Our focus is on understanding how resistance emerges in different types of bacteria during antibiotic exposure and on identifying treatment regimens that limit the emergence of resistance. We are particularly interested in repurposing existing compounds (both known antibiotics and non-antibiotics) to identify regimens with immediate clinical relevance.